Home  |  Contact



         UniProtKB/Swiss-Prot protein knowledgebase release 2019_08 statistics





1.  INTRODUCTION



Release 2019_08 of 18-Sep-19 of UniProtKB/Swiss-Prot contains 560823 sequence entries,

comprising 201585439 amino acids abstracted from 268349 references. 



289 sequences have been added since release 2019_07, the sequence data of

29 existing entries has been updated and the annotations of

187296 entries have been revised.



Number of fragments: 9175

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40155





Protein existence (PE):           entries     %



1: Evidence at protein level       101481   18.1%

2: Evidence at transcript level     57223   10.2%

3: Inferred from homology          386841     69%

4: Predicted                        13454    2.4%

5: Uncertain                         1824    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13799



   The first twenty species represent 121032 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5690

                            2x: 1974

                            3x: 1073

                            4x:  701

                            5x:  517

                            6x:  409

                            7x:  306

                            8x:  253

                            9x:  228

                           10x:  141

                       11- 20x:  768

                       21- 50x:  463

                       51-100x:  224

                         >100x: 1052





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20430  Homo sapiens (Human)

       2      17023  Mus musculus (Mouse)

       3      15892  Arabidopsis thaliana (Mouse-ear cress)

       4       8072  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6008  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4519  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4147  Dictyostelium discoideum (Slime mold)

      11       4073  Caenorhabditis elegans

      12       4051  Oryza sativa subsp. japonica (Rice)

      13       3580  Drosophila melanogaster (Fruit fly)

      14       3445  Xenopus laevis (African clawed frog)

      15       3115  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2181  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2040  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1797  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1431  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1332  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1174  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1066  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1025  Yersinia pestis

      35       1010  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        978  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        940  Emericella nidulans  

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Oryctolagus cuniculus (Rabbit)

      47        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        856  Neurospora crassa 

      56        844  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        831  Zea mays (Maize)

      60        829  Shigella boydii serotype 4 (strain Sb227)

      61        827  Canis lupus familiaris (Dog) (Canis familiaris)

      62        825  Escherichia coli (strain UTI89 / UPEC)

      63        822  Shigella dysenteriae serotype 1 (strain Sd197)

      64        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        801  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      68        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      69        791  Escherichia coli (strain SMS-3-5 / SECEC)

      70        789  Staphylococcus aureus (strain NCTC 8325)

      71        786  Aquifex aeolicus (strain VF5)

      72        776  Pasteurella multocida (strain Pm70)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        771  Escherichia coli (strain K12 / DH10B)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        742  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        721  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      97        715  Enterobacter sp. (strain 638)

      98        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella agona (strain SL483)

     102        713  Salmonella newport (strain SL254)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        677  Escherichia coli

     118        675  Staphylococcus aureus (strain USA300)

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        664  Bradyrhizobium diazoefficiens 

     124        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     125        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Shewanella oneidensis (strain MR-1)

     128        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        640  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        614  Xanthomonas campestris pv. campestris 

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        598  Pseudomonas aeruginosa (strain UCBPP-PA14)

     147        595  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     148        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        559  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     166        557  Xanthomonas axonopodis pv. citri (strain 306)

     167        555  Pseudomonas fluorescens (strain Pf0-1)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        551  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Sodalis glossinidius (strain morsitans)

     177        529  Corynebacterium glutamicum 

     178        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        524  Staphylococcus aureus (strain Newman)

     180        522  Xylella fastidiosa (strain 9a5c)

     181        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     182        517  Chromobacterium violaceum 

     183        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     184        515  Deinococcus radiodurans 

     185        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     186        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        511  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     190        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     191        510  Geobacillus kaustophilus (strain HTA426)

     192        508  Streptomyces avermitilis 

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     200        497  Haemophilus influenzae (strain 86-028NP)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Burkholderia pseudomallei (strain K96243)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Pyrococcus horikoshii 

     209        488  Methanosarcina mazei  

     210        487  Shewanella sp. (strain MR-7)

     211        486  Brucella abortus (strain 2308)

     212        486  Mannheimia succiniciproducens (strain MBEL55E)

     213        485  Thermosynechococcus elongatus (strain BP-1)

     214        484  Shewanella sp. (strain MR-4)

     215        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     216        484  Pseudomonas aeruginosa (strain LESB58)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        481  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     219        481  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     221        479  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     222        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     223        477  Pyrococcus abyssi (strain GE5 / Orsay)

     224        476  Nicotiana tabacum (Common tobacco)

     225        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     226        474  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     227        474  Burkholderia lata 

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Clostridium perfringens (strain 13 / Type A)

     231        468  Pseudomonas putida (strain GB-1)

     232        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     233        467  Shewanella frigidimarina (strain NCIMB 400)

     234        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     235        466  Aeromonas hydrophila subsp. hydrophila 

     236        466  Shewanella sp. (strain ANA-3)

     237        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     238        465  Enterococcus faecalis (strain ATCC 700802 / V583)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     241        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     242        458  Ovis aries (Sheep)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        455  Shewanella baltica (strain OS185)

     246        455  Staphylococcus aureus (strain JH1)

     247        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        453  Pseudomonas putida (strain W619)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Dechloromonas aromatica (strain RCB)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19562 (  3%)

    Bacteria         334210 ( 60%)

    Eukaryota        190190 ( 34%)

    Viruses           16861 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20431 ( 11%)           (  4%)

     Other Mammalia         46759 ( 25%)           (  8%)

     Other Vertebrata       18399 ( 10%)           (  3%)

     Viridiplantae          40084 ( 21%)           (  7%)

     Fungi                  34141 ( 18%)           (  6%)

     Insecta                 9330 (  5%)           (  2%)

     Nematoda                4982 (  3%)           (  1%)

     Other                  16064 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9670             1001-1100     4007

                 51- 100   42721             1101-1200     2811

                101- 150   59220             1201-1300     2148

                151- 200   59020             1301-1400     2015

                201- 250   57870             1401-1500     1627

                251- 300   51611             1501-1600      800

                301- 350   51987             1601-1700      621

                351- 400   45129             1701-1800      563

                401- 450   37100             1801-1900      479

                451- 500   29921             1901-2000      378

                501- 550   21630             2001-2100      250

                551- 600   15408             2101-2200      344

                601- 650   12860             2201-2300      319

                651- 700    9239             2301-2400      214

                701- 750    7675             2401-2500      164

                751- 800    5547             >2500         1318

                801- 850    4790

                851- 900    5212

                901- 950    4052

                951-1000    2928



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2823





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  897

                       2x:  404

                       3x:  167

                       4x:  130

                       5x:  112

                       6x:   99

                       7x:   74

                       8x:   57

                       9x:   36

                      10x:   33

                  11- 20x:  223

                  21- 50x:  236

                  51-100x:  121

                    >100x:  234





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24904   Journal of Biological Chemistry

    2        11588   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6670   Journal of Bacteriology

    4         5683   Biochemical and Biophysical Research Communications

    5         5401   Biochemistry

    6         5023   Nucleic Acids Research

    7         4855   FEBS Letters

    8         4819   Gene

    9         4714   The EMBO Journal

   10         4608   Nature

   11         4364   Molecular and Cellular Biology

   12         4303   Journal of Molecular Biology

   13         3683   Biochimica et Biophysica Acta

   14         3602   Cell

   15         3408   European Journal of Biochemistry

   16         3278   Journal of Virology

   17         3053   Science

   18         2884   Biochemical Journal

   19         2594   Plant Physiology

   20         2570   Molecular Microbiology

   21         2536   Genomics

   22         2212   Journal of Cell Biology

   23         2191   The American Journal of Human Genetics

   24         2026   The Plant Cell

   25         1991   PLoS ONE

   26         1872   Plant Molecular Biology

   27         1872   The Plant Journal

   28         1846   Human Molecular Genetics

   29         1843   Genes and Development

   30         1813   Virology

   31         1764   Nature Genetics

   32         1685   Molecular Biology of the Cell

   33         1681   Development

   34         1580   Human Mutation

   35         1564   Molecular Cell

   36         1543   Oncogene

   37         1499   Journal of Immunology

   38         1395   Molecular and General Genetics

   39         1364   Structure

   40         1348   Journal of Biochemistry

   41         1319   Genetics

   42         1275   Journal of Cell Science

   43         1169   Blood

   44         1149   Journal of General Virology

   45         1137   Infection and Immunity

   46         1075   Microbiology

   47         1063   Current Biology

   48         1060   Archives of Biochemistry and Biophysics

   49         1055   Developmental Biology

   50          924   Journal of Neuroscience

   51          914   Applied and Environmental Microbiology

   52          896   Acta Crystallographica, Section D

   53          887   Cancer Research

   54          845   FEMS Microbiology Letters

   55          839   Yeast

   56          784   Protein Science

   57          782   Toxicon

   58          766   Neuron

   59          746   Journal of Clinical Investigation

   60          699   Human Genetics

   61          696   American Journal of Physiology

   62          695   Plant and Cell Physiology

   63          667   PLoS Genetics

   64          660   The Journal of Experimental Medicine

   65          649   Mechanisms of Development

   66          646   Nature Structural Biology

   67          632   Proteins

   68          622   Journal of Medical Genetics

   69          582   Nature Cell Biology

   70          574   Current Genetics

   71          554   Bioscience, Biotechnology, and Biochemistry

   72          548   Nature Structural and Molecular Biology

   73          540   Journal of Neurochemistry

   74          539   Molecular Endocrinology

   75          527   The FEBS Journal

   76          521   The Journal of Clinical Endocrinology and Metabolism

   77          520   Developmental Cell

   78          506   Endocrinology

   79          499   Nature Communications

   80          488   Mammalian Genome

   81          477   Antimicrobial Agents and Chemotherapy

   82          475   Immunogenetics

   83          461   Experimental Cell Research

   84          450   Molecular and Biochemical Parasitology

   85          433   Planta

   86          432   Eukaryotic Cell

   87          419   RNA

   88          417   Scientific Reports

   89          417   Peptides

   90          407   Journal of Molecular Evolution

   91          398   Molecular Biology and Evolution

   92          398   PLoS Pathogens

   93          392   Journal of Experimental Botany

   94          391   Journal of the American Chemical Society

   95          388   DNA and Cell Biology

   96          382   Molecular Pharmacology

   97          375   DNA Sequence

   98          372   The FASEB Journal

   99          371   EMBO Reports

  100          370   Neurology

  101          367   Journal of Investigative Dermatology

  102          364   American Journal of Medical Genetics. Part A

  103          360   Acta Crystallographica, Section F

  104          356   Molecular Plant-Microbe Interactions

  105          351   Comparative Biochemistry and Physiology

  106          350   Biology of Reproduction

  107          349   European Journal of Human Genetics

  108          342   Immunity

  109          340   Brain Research. Molecular Brain Research

  110          328   Tissue Antigens

  111          326   Virus Research

  112          325   Genes to Cells

  113          322   Biochimie

  114          321   The New England Journal of Medicine

  115          315   Developmental Dynamics

  116          308   Clinical Genetics

  117          299   Genome Research

  118          298   Annals of Neurology

  119          297   Biological Chemistry Hoppe-Seyler

  120          284   European Journal of Immunology

  121          282   Cytogenetics and Cell Genetics

  122          279   BMC Genomics

  123          277   Nature Immunology

  124          271   Investigative Ophthalmology and Visual Science

  125          271   Journal of General Microbiology

  126          266   Journal of Lipid Research

  127          263   Applied Microbiology and Biotechnology

  128          260   Journal of Medicinal Chemistry

  129          260   Journal of Human Genetics

  130          257   PLoS Biology

  131          246   Archives of Microbiology

  132          239   Glycobiology

  133          234   Journal of Cellular Biochemistry

  134          232   Molecular Immunology

  135          232   Traffic

  136          232   Cell Reports

  137          231   DNA Research

  138          226   Molecular Genetics and Metabolism

  139          221   Cell Cycle

  140          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  141          217   Circulation Research

  142          215   Diabetes

  143          213   Archives of Virology

  144          210   Nature Medicine

  145          210   Phytochemistry

  146          208   Molecular and Cellular Endocrinology

  147          207   Protein Expression and Purification

  148          205   Fungal Genetics and Biology

  149          196   Molecular Genetics and Genomics

  150          190   Molecular and Cellular Neuroscience





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1231656                 2.20                                         

   Journal                           1055272     458021      1.88       1                                 

   Submitted to EMBL/GenBank/DDBJ     165482     149790      0.30       2                                 

   Submitted to other databases         7418       6848      0.01       3                                 

   Book citation                        1810       1787     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Thesis                                434        431     <0.01       6                                 

   Unpublished observations              413        409     <0.01       7                                 

   Patent                                209        203     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 416203



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2562639                 4.57                                         

   ACTIVITY REGULATION                 15234      15233      0.03      16                                 

   ALLERGEN                              861        861     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25328      25328      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8631       8631      0.02      20                                 

   BIOTECHNOLOGY                        1048       1032     <0.01      25                                 

   CATALYTIC ACTIVITY                 293018     239805      0.52       4                                 

   CAUTION                             13188      12921      0.02      18                                 

   COFACTOR                           126284     114935      0.23       7                                 

   DEVELOPMENTAL STAGE                 12371      12370      0.02      19                                 

   DISEASE                              7198       4839      0.01      21                                 

   DISRUPTION PHENOTYPE                15062      15059      0.03      17                                 

   DOMAIN                              50020      42908      0.09       9                                 

   FUNCTION                           469351     448289      0.84       2                                 

   INDUCTION                           21647      21635      0.04      14                                 

   INTERACTION                         19527      19527      0.03      15                                 

   MASS SPECTROMETRY                    6909       5286      0.01      23                                 

   MISCELLANEOUS                       38998      35818      0.07      12                                 

   PATHWAY                            139133     126087      0.25       6                                 

   PHARMACEUTICAL                        117        113     <0.01      29                                 

   POLYMORPHISM                         1332       1275     <0.01      24                                 

   PTM                                 57830      42428      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44193      44193      0.08      11                                 

   SIMILARITY                         509668     505499      0.91       1                                 

   SUBCELLULAR LOCATION               350892     343363      0.63       3                                 

   SUBUNIT                            279989     279077      0.50       5                                 

   TISSUE SPECIFICITY                  46593      46592      0.08      10                                 

   TOXIC DOSE                            675        616     <0.01      27                                 

   WEB RESOURCE                         6915       5749      0.01      22                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4554526                 8.12                                         

   ACT_SITE                           165147      99971      0.29      10                                 

   BINDING                            408760     108309      0.73       2                                 

   CA_BIND                              4206       1743      0.01      36                                 

   CARBOHYD                           116820      30063      0.21      15                                 

   CHAIN                              568853     553687      1.01       1                                 

   COILED                              22076      15277      0.04      27                                 

   COMPBIAS                            59150      31820      0.11      21                                 

   CONFLICT                           135836      47521      0.24      13                                 

   CROSSLNK                            23691       8508      0.04      26                                 

   DISULFID                           126517      34001      0.23      14                                 

   DNA_BIND                            11852      10603      0.02      32                                 

   DOMAIN                             198244     121703      0.35       9                                 

   HELIX                              265343      24318      0.47       6                                 

   INIT_MET                            17199      17199      0.03      28                                 

   INTRAMEM                             2791       1275     <0.01      37                                 

   LIPID                               13113       8465      0.02      30                                 

   METAL                              392384      95911      0.70       3                                 

   MOD_RES                            249654      72133      0.45       7                                 

   MOTIF                               43931      28684      0.08      23                                 

   MUTAGEN                             73473      15968      0.13      18                                 

   NON_CONS                             2258        789     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12439       9547      0.02      31                                 

   NP_BIND                            158312      85987      0.28      11                                 

   PEPTIDE                             11676       8044      0.02      33                                 

   PROPEP                              14349      12241      0.03      29                                 

   REGION                             201374      94709      0.36       8                                 

   REPEAT                             105809      14813      0.19      16                                 

   SIGNAL                              42355      42354      0.08      24                                 

   SITE                                59384      32280      0.11      20                                 

   STRAND                             275531      22922      0.49       5                                 

   TOPO_DOM                           141251      28929      0.25      12                                 

   TRANSIT                              9165       9049      0.02      34                                 

   TRANSMEM                           372375      77755      0.66       4                                 

   TURN                                63834      19752      0.11      19                                 

   UNSURE                               4470        806      0.01      35                                 

   VAR_SEQ                             52146      22100      0.09      22                                 

   VARIANT                             97767      17154      0.17      17                                 

   ZN_FING                             30634      13439      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18526900                33.04                                                           

   ABCD                                 1376       1376     <0.01     125      Protocols and materials databases            

   Allergome                            1912       1245     <0.01     120      Protein family/group databases               

   ArachnoServer                        1163       1154     <0.01     129      Organism-specific databases                  

   Araport                             15913      15817      0.03      81      Organism-specific databases                  

   Bgee                                56672      56671      0.10      41      Gene expression databases                    

   BindingDB                            5157       5157      0.01      98      Chemistry                                    

   BioCyc                             270050     244472      0.48      22      Enzyme and pathway databases                 

   BioGrid                             53655      51972      0.10      45      Protein-protein interaction databases        

   BioMuta                             20387      20372      0.04      67      Polymorphism and mutation databases          

   BRENDA                              12937      12163      0.02      84      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     130      PTM databases                                

   CAZy                                 9505       8568      0.02      87      Protein family/group databases               

   CCDS                                48316      34266      0.09      49      Sequence databases                           

   CDD                                184076     167127      0.33      26      Family and domain databases                  

   CGD                                  1998       1981     <0.01     119      Organism-specific databases                  

   ChEMBL                               7280       7159      0.01      93      Chemistry                                    

   ChiTaRS                             20493      20481      0.04      65      Other                                        

   CollecTF                              133        133     <0.01     152      Gene expression databases                    

   ComplexPortal                        8972       4691      0.02      88      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            952        869     <0.01     131      Organism-specific databases                  

   CORUM                                5805       5805      0.01      97      Protein-protein interaction databases        

   CPTAC                                2221       1423     <0.01     116      Proteomic databases                          

   CTD                                 75219      74320      0.13      40      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     150      PTM databases                                

   dictyBase                            4212       4098      0.01     107      Organism-specific databases                  

   DIP                                 17397      17365      0.03      77      Protein-protein interaction databases        

   DisGeNET                            15731      15500      0.03      82      Organism-specific databases                  

   DisProt                               700        700     <0.01     135      Family and domain databases                  

   DMDM                                16274      16272      0.03      80      Polymorphism and mutation databases          

   DNASU                               19014      18948      0.03      72      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     151      2D gel databases                             

   DrugBank                            27244       4521      0.05      59      Chemistry                                    

   DrugCentral                          2531       2531     <0.01     114      Chemistry                                    

   EchoBASE                             4159       4159      0.01     108      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     104      Organism-specific databases                  

   eggNOG                             666020     332282      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     121      Protein-protein interaction databases        

   EMBL                               985489     548819      1.76       3      Sequence databases                           

   Ensembl                             91819      50595      0.16      39      Genome annotation databases                  

   EnsemblBacteria                    355841     336671      0.63      16      Genome annotation databases                  

   EnsemblFungi                        29524      27969      0.05      55      Genome annotation databases                  

   EnsemblMetazoa                      17590      10310      0.03      75      Genome annotation databases                  

   EnsemblPlants                       27988      20951      0.05      57      Genome annotation databases                  

   EnsemblProtists                      4876       4698      0.01     101      Genome annotation databases                  

   EPD                                 22060      22060      0.04      63      Proteomic databases                          

   ESTHER                               2537       2536     <0.01     113      Protein family/group databases               

   euHCVdb                                55         44     <0.01     155      Organism-specific databases                  

   EuPathDB                            19678      19666      0.04      71      Organism-specific databases                  

   EvolutionaryTrace                   16641      16641      0.03      79      Other                                        

   ExpressionAtlas                     49462      49462      0.09      48      Gene expression databases                    

   FlyBase                              4885       4759      0.01     100      Organism-specific databases                  

   Gene3D                             391296     305528      0.70      15      Family and domain databases                  

   GeneCards                           20414      20241      0.04      66      Organism-specific databases                  

   GeneDB                                579        523     <0.01     139      Genome annotation databases                  

   GeneID                             291148     280536      0.52      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     122      Organism-specific databases                  

   GeneTree                            55846      55796      0.10      42      Phylogenomic databases                       

   Genevisible                         55241      55241      0.10      43      Gene expression databases                    

   GeneWiki                            10355      10272      0.02      86      Other                                        

   GenomeRNAi                          22139      22139      0.04      62      Other                                        

   GlyConnect                           2250       2162     <0.01     115      PTM databases                                

   GO                                2975493     535489      5.31       1      Ontologies                                   

   Gramene                             27988      20951      0.05      56      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1998       1998     <0.01     118      Chemistry                                    

   HAMAP                              330052     327149      0.59      17      Family and domain databases                  

   HGNC                                20374      20235      0.04      68      Organism-specific databases                  

   HOGENOM                            392148     392148      0.70      14      Phylogenomic databases                       

   HPA                                 27385      16820      0.05      58      Organism-specific databases                  

   IMGT_GENE-DB                          266        266     <0.01     149      Protein family/group databases               

   InParanoid                         139794     139794      0.25      29      Phylogenomic databases                       

   IntAct                              54659      54659      0.10      44      Protein-protein interaction databases        

   InterPro                          2289733     542061      4.08       2      Family and domain databases                  

   iPTMnet                             52630      52630      0.09      46      PTM databases                                

   jPOST                               26850      26850      0.05      60      Proteomic databases                          

   KEGG                               504623     475721      0.90       7      Genome annotation databases                  

   KO                                 407294     406848      0.73      13      Phylogenomic databases                       

   LegioList                             765        763     <0.01     134      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     140      Organism-specific databases                  

   MalaCards                            4674       4670      0.01     102      Organism-specific databases                  

   MassIVE                             17528      17528      0.03      76      Proteomic databases                          

   MaxQB                               29641      29641      0.05      54      Proteomic databases                          

   MEROPS                              11433      11432      0.02      85      Protein family/group databases               

   MGI                                 16933      16893      0.03      78      Organism-specific databases                  

   MIM                                 21349      15196      0.04      64      Organism-specific databases                  

   MINT                                22632      22632      0.04      61      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              280        280     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20349      20349      0.04      69      Organism-specific databases                  

   NIAGADS                                72         72     <0.01     154      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                409803     409803      0.73      12      Phylogenomic databases                       

   OpenTargets                         18424      18270      0.03      73      Organism-specific databases                  

   Orphanet                             7547       3997      0.01      92      Organism-specific databases                  

   OrthoDB                            257050     257050      0.46      23      Phylogenomic databases                       

   PANTHER                            281255     269679      0.50      21      Family and domain databases                  

   PATRIC                              92076      92076      0.16      38      Genome annotation databases                  

   PaxDb                              124834     124834      0.22      32      Proteomic databases                          

   PDB                                182527      27992      0.33      27      3D structure databases                       

   PDBsum                             182527      27992      0.33      28      3D structure databases                       

   PeptideAtlas                        32539      32539      0.06      53      Proteomic databases                          

   PeroxiBase                            782        760     <0.01     133      Protein family/group databases               

   Pfam                               780476     521913      1.39       4      Family and domain databases                  

   PharmGKB                            18354      18311      0.03      74      Organism-specific databases                  

   Pharos                              20196      20196      0.04      70      Other                                        

   PhosphoSitePlus                     39019      39019      0.07      52      PTM databases                                

   PhylomeDB                           96431      96431      0.17      36      Phylogenomic databases                       

   PIR                                124327     113862      0.22      33      Sequence databases                           

   PIRSF                              108965     107936      0.19      35      Family and domain databases                  

   PMAP-CutDB                           1401       1401     <0.01     123      Other                                        

   PomBase                              5132       5128      0.01      99      Organism-specific databases                  

   PRIDE                              234519     234519      0.42      24      Proteomic databases                          

   PRINTS                             131688     117012      0.23      31      Family and domain databases                  

   PRO                                 95973      95973      0.17      37      Other                                        

   ProMEX                                462        462     <0.01     142      Proteomic databases                          

   PROSITE                            472224     300600      0.84      10      Family and domain databases                  

   Proteomes                          484248     459878      0.86       9      Other                                        

   ProteomicsDB                        40940      19905      0.07      51      Proteomic databases                          

   PseudoCAP                            1340       1331     <0.01     126      Organism-specific databases                  

   Reactome                           118828      36261      0.21      34      Enzyme and pathway databases                 

   REBASE                                405        405     <0.01     143      Protein family/group databases               

   RefSeq                             612212     466561      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  7995       7994      0.01      91      Organism-specific databases                  

   SABIO-RK                             4263       4263      0.01     106      Enzyme and pathway databases                 

   SFLD                                 8103       6014      0.01      90      Family and domain databases                  

   SGD                                  6740       6735      0.01      95      Organism-specific databases                  

   SignaLink                            3069       3069      0.01     112      Enzyme and pathway databases                 

   SIGNOR                               4265       4265      0.01     105      Enzyme and pathway databases                 

   SMART                              192976     142315      0.34      25      Family and domain databases                  

   SMR                                445567     445567      0.79      11      3D structure databases                       

   STRING                             328516     328516      0.59      18      Protein-protein interaction databases        

   SUPFAM                             499568     378804      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1391       1304     <0.01     124      Chemistry                                    

   SwissPalm                            8656       8656      0.02      89      PTM databases                                

   TAIR                                14698      14642      0.03      83      Organism-specific databases                  

   TCDB                                 7144       7095      0.01      94      Protein family/group databases               

   TIGRFAMs                           292568     272568      0.52      19      Family and domain databases                  

   TopDownProteomics                    3240       2963      0.01     110      Proteomic databases                          

   TreeFam                             45585      45575      0.08      50      Phylogenomic databases                       

   TubercuList                          2199       2163     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     141      2D gel databases                             

   UCSC                                50074      45729      0.09      47      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     137      PTM databases                                

   UniLectin                             275        275     <0.01     148      Protein family/group databases               

   UniPathway                         136954     124008      0.24      30      Enzyme and pathway databases                 

   VectorBase                            581        502     <0.01     138      Genome annotation databases                  

   VGNC                                 3964       3964      0.01     109      Organism-specific databases                  

   WBParaSite                             32         32     <0.01     156      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     132      2D gel databases                             

   WormBase                             6149       4672      0.01      96      Organism-specific databases                  

   Xenbase                              4665       4610      0.01     103      Organism-specific databases                  

   ZFIN                                 3093       3088      0.01     111      Organism-specific databases                  



Total number of cross-referenced databases: 156



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3917 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79548